Requirement of UNC93B1 reveals a critical role for Toll-Like Receptor 7 in host resistance to primary infection with Trypanosoma cruzi,

UNC93B1 associates with Toll-Like Receptor (TLR) 3, 7 and 9, mediating their translocation from the endoplasmic reticulum to the endolysosome, thus allowing proper activation by microbial nucleic acids. We found that the triple deficient ‘3d’ mice, which lack functional UNC93B1 as well as functional...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Caetano, Braulia C., Carmo, Bianca B., Melo, Mariane B., Cerny, Anna, dos Santos, Sara L., Bartholomeu, Daniella C., Golenbock, Douglas T., Gazzinelli, Ricardo T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150366/
https://ncbi.nlm.nih.gov/pubmed/21753151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003911
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares