TAT-Mediated Transduction of MafA Protein In Utero Results in Enhanced Pancreatic Insulin Expression and Changes in Islet Morphology

Alongside Pdx1 and Beta2/NeuroD, the transcription factor MafA has been shown to be instrumental in the maintenance of the beta cell phenotype. Indeed, a combination of MafA, Pdx1 and Ngn3 (an upstream regulator of Beta2/NeuroD) was recently reported to lead to the effective reprogramming of acinar...

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Detalhes bibliográficos
Main Authors: Vargas, Nancy, Álvarez-Cubela, Silvia, Giraldo, Jaime A., Nieto, Margarita, Fort, Nicholas M., Cechin, Sirlene, García, Enrique, Espino-Grosso, Pedro, Fraker, Christopher A., Ricordi, Camillo, Inverardi, Luca, Pastori, Ricardo L., Domínguez-Bendala, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150355/
https://ncbi.nlm.nih.gov/pubmed/21857924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022364
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