Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources

We present a method of targeted DNA sequence retrieval from DNA sources which are heavily degraded and contaminated with microbial DNA, as is typical of ancient bones. The method greatly reduces sample destruction and sequencing demands relative to direct PCR or shotgun sequencing approaches. We use...

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Bibliografiska uppgifter
Huvudupphovsmän: Briggs, Adrian W., Good, Jeffrey M., Green, Richard E., Krause, Johannes, Maricic, Tomislav, Stenzel, Udo, Pääbo, Svante
Materialtyp: Artigo
Språk:Inglês
Publicerad: MyJove Corporation 2009
Ämnen:
Cellular Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150061/
https://ncbi.nlm.nih.gov/pubmed/19730410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/1573
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