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Response to Combined Molecular Targeting: Defining the Role of P-STAT3

Src family kinase- (SFK-) targeting agents are currently undergoing clinical investigation for treatment of solid malignancies. EGFR-independent phosphorylation of STAT3 (P-STAT3) has been identified as a mechanism of tumor resistance to agents targeting SFK. Tumor P-STAT3 levels may be an important...

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Bibliographic Details
Main Authors: Egloff, Ann Marie, Grandis, Jennifer R.
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149866/
https://ncbi.nlm.nih.gov/pubmed/21266530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2925
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