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The unfolded protein response and proteostasis in Alzheimer disease: Preferential activation of autophagy by endoplasmic reticulum stress

Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore proteostasis in the ER. Previously, we demonstrated that UPR activation is an early event in Alzheimer disease (AD) brain. In our recent work we investigated wheth...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Scheper, Wiep, Nijholt, Diana AT, Hoozemans, Jeroen JM
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Landes Bioscience 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149694/
https://ncbi.nlm.nih.gov/pubmed/21494086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.8.15761
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