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Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

Protein folding stress in the endoplasmic reticulum (ER) may lead to activation of the unfolded protein response (UPR), aimed to restore cellular homeostasis via transcriptional and post-transcriptional mechanisms. ER stress is also reported to activate the ER overload response (EOR), which activate...

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Detalhes bibliográficos
Main Authors: Nijholt, D A T, de Graaf, T R, van Haastert, E S, Oliveira, A Osório, Berkers, C R, Zwart, R, Ovaa, H, Baas, F, Hoozemans, J J M, Scheper, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131935/
https://ncbi.nlm.nih.gov/pubmed/21252911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.176
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