Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II

The ubiquitous enzyme carbonic anhydrase isoform II (CAII) has been shown to enhance transport activity of the proton-coupled monocarboxylate transporters MCT1 and MCT4 in a non-catalytic manner. In this study, we investigated the role of cytosolic CAII and of the extracellular, membrane-bound CA is...

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Bibliographic Details
Main Authors: Klier, Michael, Schüler, Christina, Halestrap, Andrew P., Sly, William S., Deitmer, Joachim W., Becker, Holger M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149368/
https://ncbi.nlm.nih.gov/pubmed/21680735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255331
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