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A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice
Lung tumors from smokers as well as lung tumors from mice exposed to tobacco carcinogens such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), often carry mutations in K-ras, which activates downstream-signaling pathways such as PI3K/AKT/mTOR pathway. Mice with genetic deletion of one of thr...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149208/ https://ncbi.nlm.nih.gov/pubmed/21625009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr097 |
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