Several rAAV Vectors Efficiently Cross the Blood–brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System

Noninvasive systemic gene delivery to the central nervous system (CNS) has largely been impeded by the blood–brain barrier (BBB). Recent studies documented widespread CNS gene transfer after intravascular delivery of recombinant adeno-associated virus 9 (rAAV9). To investigate alternative and possib...

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Detalhes bibliográficos
Main Authors: Zhang, Hongwei, Yang, Bin, Mu, Xin, Ahmed, Seemin Seher, Su, Qin, He, Ran, Wang, Hongyan, Mueller, Christian, Sena-Esteves, Miguel, Brown, Robert, Xu, Zuoshang, Gao, Guangping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149178/
https://ncbi.nlm.nih.gov/pubmed/21610699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.98
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