A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response

The purpose of this study was to investigate the host response to systemically administered lipid nanoparticles (NPs) encapsulating plasmid DNA (pDNA) in the spleen using a DNA microarray. As a model for NPs, we used a multifunctional envelope-type nano device (MEND). Microarray analysis revealed th...

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Main Authors: Hatakeyama, Hiroto, Ito, Erika, Yamamoto, Momoko, Akita, Hidetaka, Hayashi, Yasuhiro, Kajimoto, Kazuaki, Kaji, Noritada, Baba, Yoshinobu, Harashima, Hideyoshi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149170/
https://ncbi.nlm.nih.gov/pubmed/21386823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.24
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