A DNA Microarray-based Analysis of the Host Response to a Nonviral Gene Carrier: A Strategy for Improving the Immune Response

The purpose of this study was to investigate the host response to systemically administered lipid nanoparticles (NPs) encapsulating plasmid DNA (pDNA) in the spleen using a DNA microarray. As a model for NPs, we used a multifunctional envelope-type nano device (MEND). Microarray analysis revealed th...

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Bibliografiske detaljer
Main Authors: Hatakeyama, Hiroto, Ito, Erika, Yamamoto, Momoko, Akita, Hidetaka, Hayashi, Yasuhiro, Kajimoto, Kazuaki, Kaji, Noritada, Baba, Yoshinobu, Harashima, Hideyoshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149170/
https://ncbi.nlm.nih.gov/pubmed/21386823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.24
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