Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer

Notch signaling, a key regulator of stem cells, is frequently overactivated in cancer. It is often linked to aggressive forms of cancer, evading standard treatment highlighting Notch as an exciting therapeutic target. Notch is in principle “druggable” by γ-secretase inhibitors (GSIs), inhibitory pep...

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Bibliographische Detailangaben
Hauptverfasser: Mamaeva, Veronika, Rosenholm, Jessica M, Bate-Eya, Laurel Tabe, Bergman, Lotta, Peuhu, Emilia, Duchanoy, Alain, Fortelius, Lina E, Landor, Sebastian, Toivola, Diana M, Lindén, Mika, Sahlgren, Cecilia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2011
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149161/
https://ncbi.nlm.nih.gov/pubmed/21629222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.105
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