Successful generation of primary virus-specific and anti-tumor T-cell responses from the naïve donor T-cell repertoire is determined by the balance between antigen-specific precursor T cells and regulatory T cells

BACKGROUND: One of the major challenges in allogeneic stem cell transplantation is to find a balance between the harmful induction of graft-versus-host disease and the beneficial graft-versus-leukemia and pathogen-specific immune responses. Adoptive transfer of in-vitro generated donor T cells with...

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Detalhes bibliográficos
Main Authors: Jedema, Inge, van de Meent, Marian, Pots, Jeanette, Kester, Michel G.D., van der Beek, Martha T., Falkenburg, J.H. Frederik
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148915/
https://ncbi.nlm.nih.gov/pubmed/21546501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.039099
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