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E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the retinoblastoma tumor suppressor protein (pRB). Here we show that E2F1 is a potent and specific inhibitor of β-catenin/T-cell factor (TCF)-dependent transcription, and that this...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3148807/ https://ncbi.nlm.nih.gov/pubmed/18794899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07310 |
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