E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the retinoblastoma tumor suppressor protein (pRB). Here we show that E2F1 is a potent and specific inhibitor of β-catenin/T-cell factor (TCF)-dependent transcription, and that this...

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Bibliografiske detaljer
Main Authors: Morris, Erick J., Ji, Jun-Yuan, Yang, Fajun, Di Stefano, Luisa, Herr, Anabel, Moon, Nam-Sung, Kwon, Eun-Jeong, Haigis, Kevin M., Näär, Anders M., Dyson, Nicholas J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148807/
https://ncbi.nlm.nih.gov/pubmed/18794899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07310
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