Active repression and E2F inhibition by pRB are biochemically distinguishable

To understand mechanistically how pRB represses transcription, we used a reconstituted transcription assay and compared pRB activity on naked versus chromatin templates. Surprisingly, when pRB was directly recruited to a naked template, no transcriptional repression was observed. However, we observe...

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Detaylı Bibliyografya
Asıl Yazarlar: Ross, John F., Näär, Anders, Cam, Hieu, Gregory, Richard, Dynlacht, Brian David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2001
Konular:
Research Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC312635/
https://ncbi.nlm.nih.gov/pubmed/11230147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.858501
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