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Active repression and E2F inhibition by pRB are biochemically distinguishable
To understand mechanistically how pRB represses transcription, we used a reconstituted transcription assay and compared pRB activity on naked versus chromatin templates. Surprisingly, when pRB was directly recruited to a naked template, no transcriptional repression was observed. However, we observe...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2001
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312635/ https://ncbi.nlm.nih.gov/pubmed/11230147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.858501 |
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