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Shock and awe: unleashing the heat shock response to treat Huntington disease
The heat shock response (HSR) is a highly conserved protective mechanism that enables cells to withstand diverse environmental stressors that disrupt protein homeostasis (proteostasis) and promote protein misfolding. It has been suggested that small-molecule drugs that elicit the HSR by activating t...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3148752/ https://ncbi.nlm.nih.gov/pubmed/21785212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59190 |
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