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Shock and awe: unleashing the heat shock response to treat Huntington disease

The heat shock response (HSR) is a highly conserved protective mechanism that enables cells to withstand diverse environmental stressors that disrupt protein homeostasis (proteostasis) and promote protein misfolding. It has been suggested that small-molecule drugs that elicit the HSR by activating t...

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Autori principali: Jackrel, Meredith E., Shorter, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148752/
https://ncbi.nlm.nih.gov/pubmed/21785212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59190
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