3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

A fine balance between bone resorption by osteoclasts and bone formation by osteoblasts maintains bone homeostasis. In patients with cherubism, gain-of-function mutations in 3BP2, which is encoded by SH3-domain binding protein 2 (SH3BP2), cause cystic lesions with activated osteoclasts that lead to...

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Hauptverfasser: Levaot, Noam, Simoncic, Paul D., Dimitriou, Ioannis D., Scotter, Andrew, La Rose, Jose, Ng, Adeline H.M., Willett, Thomas L., Wang, Chiachien J., Janmohamed, Salima, Grynpas, Marc, Reichenberger, Ernst, Rottapel, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148735/
https://ncbi.nlm.nih.gov/pubmed/21765218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45843
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