Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties

Cherubism is an autosomal dominant disorder in children characterized by unwarranted symmetrical bone resorption of the jaws with fibrous tissue deposition. Mutations causing cherubism have been identified in the adaptor protein SH3BP2. Knock-in mice with a Pro416Arg mutation in Sh3bp2 exhibit a gen...

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Hlavní autoři: Wang, Chiachien J., Chen, I-Ping, Koczon-Jaremko, Boguslawa, Boskey, Adele L., Ueki, Yasuyoshi, Kuhn, Liisa, Reichenberger, Ernst J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854251/
https://ncbi.nlm.nih.gov/pubmed/20117257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2010.01.380
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