Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes

The failure of pancreatic β cells to adapt to an increasing demand for insulin is the major mechanism by which patients progress from insulin resistance to type 2 diabetes (T2D) and is thought to be related to dysfunctional lipid homeostasis within those cells. In multiple animal models of diabetes,...

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Main Authors: Tiano, Joseph P., Delghingaro-Augusto, Viviane, Le May, Cedric, Liu, Suhuan, Kaw, Meenakshi K., Khuder, Saja S., Latour, Martin G., Bhatt, Surabhi A., Korach, Kenneth S., Najjar, Sonia M., Prentki, Marc, Mauvais-Jarvis, Franck
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148728/
https://ncbi.nlm.nih.gov/pubmed/21747171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44564
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