VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling

Autosomal recessive primary microcephaly (MCPH) is a genetic disorder that causes a reduction of cortical outgrowth without severe interference with cortical patterning. It is associated with mutations in a number of genes encoding protein involved in mitotic spindle formation and centrosomal activi...

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Autors principals: Passemard, Sandrine, El Ghouzzi, Vincent, Nasser, Hala, Verney, Catherine, Vodjdani, Guilan, Lacaud, Adrien, Lebon, Sophie, Laburthe, Marc, Robberecht, Patrick, Nardelli, Jeannette, Mani, Shyamala, Verloes, Alain, Gressens, Pierre, Lelièvre, Vincent
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148726/
https://ncbi.nlm.nih.gov/pubmed/21737879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43824
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