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Early detection and treatment of wear particle-induced inflammation and bone loss in a mouse calvarial osteolysis model using HPMA copolymer conjugates

Wear particle-induced inflammation is considered to be the major cause of aseptic implant loosening and clinical failure after total joint replacement. Due to the frequent absence of symptoms, early detection and intervention prior to implant failure presents a significant challenge. To address this...

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Autors principals: Ren, Ke, Purdue, P. Edward, Burton, Lyndsey, Quan, Ling-dong, Fehringer, Edward V., Thiele, Geoffrey M., Goldring, Steven R., Wang, Dong
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148351/
https://ncbi.nlm.nih.gov/pubmed/21438611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp2000555
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