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Inhibition of p53 by Adenovirus Type 12 E1B-55K Deregulates Cell Cycle Control and Sensitizes Tumor Cells to Genotoxic Agents

Adenovirus E1B-55K represses p53-mediated transcription. However, the phenotypic consequence of p53 inhibition by E1B-55K for cell cycle regulation and drug sensitivity in tumor cells has not been examined. In HCT116 cells with constitutive E1B-55K expression, the activation of p53 target genes such...

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Autori principali: Li, Qiang, Zhao, Lisa Y., Zheng, Zhi, Yang, Heng, Santiago, Aleixo, Liao, Daiqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147969/
https://ncbi.nlm.nih.gov/pubmed/21680522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00492-11
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