Assessment of the Genetic Susceptibility of Sheep to Scrapie by Protein Misfolding Cyclic Amplification and Comparison with Experimental Scrapie Transmission Studies

The susceptibility of sheep to scrapie is influenced mainly by the prion protein polymorphisms A136V, R154H, and Q171R/H. Here we analyzed the ability of protein misfolding cyclic amplification (PMCA) to model the genetic susceptibility of sheep to scrapie. For this purpose, we studied the efficienc...

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Bibliografiske detaljer
Main Authors: Bucalossi, Cecilia, Cosseddu, GianMario, D'Agostino, Claudia, Di Bari, Michele Angelo, Chiappini, Barbara, Conte, Michela, Rosone, Francesca, De Grossi, Luigi, Scavia, Gaia, Agrimi, Umberto, Nonno, Romolo, Vaccari, Gabriele
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147950/
https://ncbi.nlm.nih.gov/pubmed/21680531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00241-11
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