Genetic Editing of Herpes Simplex Virus 1 and Epstein-Barr Herpesvirus Genomes by Human APOBEC3 Cytidine Deaminases in Culture and In Vivo

Human APOBEC3 cytidine deaminases target and edit single-stranded DNA, which can be of viral, mitochondrial, or nuclear origin. Retrovirus genomes, such as human immunodeficiency virus (HIV) genomes deficient in the vif gene and the hepatitis B virus genome, are particularly vulnerable. The genomes...

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Detalhes bibliográficos
Main Authors: Suspène, Rodolphe, Aynaud, Marie-Ming, Koch, Stefanie, Pasdeloup, David, Labetoulle, Marc, Gaertner, Barbara, Vartanian, Jean-Pierre, Meyerhans, Andreas, Wain-Hobson, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147940/
https://ncbi.nlm.nih.gov/pubmed/21632763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00290-11
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