A Single Amino Acid in Nonstructural Protein NS4B Confers Virulence to Dengue Virus in AG129 Mice through Enhancement of Viral RNA Synthesis

Dengue (DEN) is a mosquito-borne viral disease that has become an increasing economic and health burden for the tropical and subtropical world. The lack of an appropriate animal model of DEN has greatly impeded the study of its pathogenesis and the development of vaccines/antivirals. We recently rep...

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Main Authors: Grant, Dixon, Tan, Grace K., Qing, Min, Ng, Jowin K. W., Yip, Andy, Zou, Gang, Xie, Xuping, Yuan, Zhiming, Schreiber, Mark J., Schul, Wouter, Shi, Pei-Yong, Alonso, Sylvie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147917/
https://ncbi.nlm.nih.gov/pubmed/21632767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00665-11
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