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A Single Amino Acid in Nonstructural Protein NS4B Confers Virulence to Dengue Virus in AG129 Mice through Enhancement of Viral RNA Synthesis

Dengue (DEN) is a mosquito-borne viral disease that has become an increasing economic and health burden for the tropical and subtropical world. The lack of an appropriate animal model of DEN has greatly impeded the study of its pathogenesis and the development of vaccines/antivirals. We recently rep...

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Detalhes bibliográficos
Main Authors: Grant, Dixon, Tan, Grace K., Qing, Min, Ng, Jowin K. W., Yip, Andy, Zou, Gang, Xie, Xuping, Yuan, Zhiming, Schreiber, Mark J., Schul, Wouter, Shi, Pei-Yong, Alonso, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147917/
https://ncbi.nlm.nih.gov/pubmed/21632767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00665-11
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