PINCH Proteins Regulate Cardiac Contractility by Modulating Integrin-Linked Kinase-Protein Kinase B Signaling

Integrin-linked kinase (ILK) is an essential component of the cardiac mechanical stretch sensor and is bound in a protein complex with parvin and PINCH proteins, the so-called ILK-PINCH-parvin (IPP) complex. We have recently shown that inactivation of ILK or β-parvin activity leads to heart failure...

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Autori principali: Meder, Benjamin, Huttner, Inken G., Sedaghat-Hamedani, Farbod, Just, Steffen, Dahme, Tillman, Frese, Karen S., Vogel, Britta, Köhler, Doreen, Kloos, Wanda, Rudloff, Jessica, Marquart, Sabine, Katus, Hugo A., Rottbauer, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147799/
https://ncbi.nlm.nih.gov/pubmed/21670146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05269-11
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