Piperaquine Resistance Is Associated with a Copy Number Variation on Chromosome 5 in Drug-Pressured Plasmodium falciparum Parasites

The combination of piperaquine and dihydroartemisinin has recently become the official first-line therapy in several Southeast Asian countries. The pharmacokinetic mismatching of these drugs, whose plasma half-lives are ∼20 days and ∼1 h, respectively, implies that recrudescent or new infections eme...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Eastman, Richard T., Dharia, Neekesh V., Winzeler, Elizabeth A., Fidock, David A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2011
Gaiak:
Mechanisms of Resistance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147642/
https://ncbi.nlm.nih.gov/pubmed/21576453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01793-10
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