Plasmodium falciparum Isolates with Increased pfmdr1 Copy Number Circulate in West Africa

Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins. We demonstrate here that duplicated pfmdr1 genotypes circulate in West Africa. The monitoring of this prevalence in Africa appears essential for determining...

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Hlavní autoři: Witkowski, Benoit, Nicolau, Marie-Laure, Soh, Patrice Njomnang, Iriart, Xavier, Menard, Sandie, Alvarez, Muriel, Marchou, Bruno, Magnaval, Jean-François, Benoit-Vical, Françoise, Berry, Antoine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897320/
https://ncbi.nlm.nih.gov/pubmed/20404118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00209-10
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