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Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism
Small heat shock proteins (sHsps) are molecular chaperones that protect cells from cytotoxic effects of protein misfolding and aggregation. HspB1, an sHsp commonly associated with senile plaques in Alzheimer's disease (AD), prevents the toxic effects of Aβ aggregates in vitro. However, the mech...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3147607/ https://ncbi.nlm.nih.gov/pubmed/21670152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01187-10 |
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