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Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism

Small heat shock proteins (sHsps) are molecular chaperones that protect cells from cytotoxic effects of protein misfolding and aggregation. HspB1, an sHsp commonly associated with senile plaques in Alzheimer's disease (AD), prevents the toxic effects of Aβ aggregates in vitro. However, the mech...

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Main Authors: Ojha, Juhi, Masilamoni, Gunasingh, Dunlap, David, Udoff, Ross A., Cashikar, Anil G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147607/
https://ncbi.nlm.nih.gov/pubmed/21670152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01187-10
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