Development of a Streptomyces venezuelae-Based Combinatorial Biosynthetic System for the Production of Glycosylated Derivatives of Doxorubicin and Its Biosynthetic Intermediates

Doxorubicin, one of the most widely used anticancer drugs, is composed of a tetracyclic polyketide aglycone and l-daunosamine as a deoxysugar moiety, which acts as an important determinant of its biological activity. This is exemplified by the fewer side effects of semisynthetic epirubicin (4′-epi-d...

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Detalhes bibliográficos
Main Authors: Han, Ah Reum, Park, Je Won, Lee, Mi Kyeong, Ban, Yeon Hee, Yoo, Young Ji, Kim, Eun Ji, Kim, Eunji, Kim, Byung-Gee, Sohng, Jae Kyung, Yoon, Yeo Joon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147398/
https://ncbi.nlm.nih.gov/pubmed/21602397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02527-10
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