Enhanced Heterologous Production of Desosaminyl Macrolides and Their Hydroxylated Derivatives by Overexpression of the pikD Regulatory Gene in Streptomyces venezuelae

To elevate the production level of heterologous polyketide in Streptomyces venezuelae, an additional copy of the positive regulatory gene pikD was introduced into the pikromycin (Pik) polyketide synthase (PKS) deletion mutant of S. venezuelae ATCC 15439 expressing tylosin PKS genes. The resulting mu...

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Detalhes bibliográficos
Main Authors: Jung, Won Seok, Jeong, Soon Jeong, Park, Sung Ryeol, Choi, Cha Yong, Park, Byoung Chul, Park, Je Won, Yoon, Yeo Joon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Physiology and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292611/
https://ncbi.nlm.nih.gov/pubmed/18245260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02296-07
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