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Dual Function Inhibitors of Relevance to Chronic Obstructive Pulmonary Disease

The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual functio...

詳細記述

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書誌詳細
主要な著者: Dou, Dengfeng, He, Guijia, Alliston, Kevin R., Groutas, William C.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147253/
https://ncbi.nlm.nih.gov/pubmed/21511470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.12.033
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