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Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants
Background Mendelian Randomization (MR) studies assess the causality of an exposure–disease association using genetic determinants [i.e. instrumental variables (IVs)] of the exposure. Power and IV strength requirements for MR studies using multiple genetic variants have not been explored. Methods We...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3147064/ https://ncbi.nlm.nih.gov/pubmed/20813862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyq151 |
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