Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

Background Mendelian Randomization (MR) studies assess the causality of an exposure–disease association using genetic determinants [i.e. instrumental variables (IVs)] of the exposure. Power and IV strength requirements for MR studies using multiple genetic variants have not been explored. Methods We...

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Bibliografiske detaljer
Main Authors: Pierce, Brandon L, Ahsan, Habibul, VanderWeele, Tyler J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Theory and Methods
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147064/
https://ncbi.nlm.nih.gov/pubmed/20813862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyq151
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