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The Loss of HIF1α Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts

Wild-type and HIF1α −/− MEF cells were used to determine the role of HIF1α in cadmium-induced toxicity. Cadmium treatment did not affect HIF1-mediated transcription but led to caspase activation and apoptotic cell death in wild-type and HIF1α −/− cells. Cadmium-induced cell death, however, was signi...

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Библиографические подробности
Главные авторы: Vengellur, Ajith, Grier, Elizabeth, LaPres, John J.
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147003/
https://ncbi.nlm.nih.gov/pubmed/21811500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/391074
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