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Allosteric drugs: the interaction of anti-tumor compound MKT-077 with human Hsp70 chaperones
The Hsp70 chaperones (Heat shock protein 70 kDa) are key to cellular protein homeostatis. However, they also have the ability to inhibit tumor apoptosis, and contribute to aberrant accumulation of hyperphosphorylated tau in neuronal cells affected by tauopathies, including Alzheimer’s disease. Hence...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3146629/ https://ncbi.nlm.nih.gov/pubmed/21708173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.06.003 |
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