Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid-β Accumulation and Independently Accelerates the Development of Tau Abnormalities

Alzheimer's disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affec...

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Autores principales: Tran, Hien T., LaFerla, Frank M., Holtzman, David M., Brody, David L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2011
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146343/
https://ncbi.nlm.nih.gov/pubmed/21715616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0858-11.2011
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