Active immunization using a single dose immunotherapeutic abates established EAE via IL-10 and regulatory T cells

Stimulation of Ag-specific inducible Treg can enhance resolution of autoimmune disease. Conventional methods to induce Treg often require induction of autoimmune disease or subjection to infection. Reovirus adhesin, protein σ1 (pσ1), can successfully facilitate tolerance when fused to a tolerogen. W...

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Bibliografiske detaljer
Main Authors: Rynda-Apple, Agnieszka, Huarte, Eduardo, Maddaloni, Massimo, Callis, Gayle, Skyberg, Jerod A., Pascual, David W.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145764/
https://ncbi.nlm.nih.gov/pubmed/21268002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201041104
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