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Autoimmune regulator (AIRE)-deficient CD8(+)CD28(low) regulatory T lymphocytes fail to control experimental colitis
Mutations in the gene encoding the transcription factor autoimmune regulator (AIRE) are responsible for autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome. AIRE directs expression of tissue-restricted antigens in the thymic medulla and in lymph node stromal cells and thereby sub...
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主要な著者: | , , , , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
National Academy of Sciences
2011
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145727/ https://ncbi.nlm.nih.gov/pubmed/21746930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107136108 |
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