Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity

Inflammasomes are intracellular multiprotein signaling complexes that activate Caspase-1, leading to the cleavage and secretion of IL-1β and IL-18, and ultimately host cell death. Inflammasome activation is a common cellular response to infection; however, the consequences of inflammasome activation...

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Autori principali: Sauer, John-Demian, Pereyre, Sabine, Archer, Kristina A., Burke, Thomas P., Hanson, Bill, Lauer, Peter, Portnoy, Daniel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145703/
https://ncbi.nlm.nih.gov/pubmed/21746921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019041108
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