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Inflammasome-Mediated Inhibition of Listeria monocytogenes-Stimulated Immunity Is Independent of Myelomonocytic Function

Activation of the Nlrc4 inflammasome results in the secretion of IL-1β and IL-18 through caspase-1 and induction of pyroptosis. L. monocytogenes engineered to activate Nlrc4 by expression of Legionella pneumophilia flagellin (L. monocytogenes L.p.FlaA) are less immunogenic for CD8(+) T cell response...

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Detalhes bibliográficos
Main Authors: Williams, Cassandra R., Dustin, Michael L., Sauer, John-Demian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857309/
https://ncbi.nlm.nih.gov/pubmed/24349458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083191
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