載入...
Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening
The question of how dispersed mutations in one protein engender the same gain-of-function phenotype is of great interest. Here we focus on mutations in glycyl-tRNA synthetase (GlyRS) that cause an axonal form of Charcot–Marie–Tooth (CMT) diseases, the most common hereditary peripheral neuropathies....
Na minha lista:
| Main Authors: | , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2011
|
| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145702/ https://ncbi.nlm.nih.gov/pubmed/21737751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104293108 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|