Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ2 renders tumor cells dependent on its paralogous gene COPZ1

Anticancer drugs are effective against tumors that depend on the molecular target of the drug. Known targets of cytotoxic anticancer drugs are involved in cell proliferation; drugs acting on such targets are ineffective against nonproliferating tumor cells, survival of which leads to eventual therap...

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Detalhes bibliográficos
Main Authors: Shtutman, Michael, Baig, Mirza, Levina, Elina, Hurteau, Gregory, Lim, Chang-uk, Broude, Eugenia, Nikiforov, Mikhail, Harkins, Timothy T., Carmack, C. Steven, Ding, Ye, Wieland, Felix, Buttyan, Ralph, Roninson, Igor B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145676/
https://ncbi.nlm.nih.gov/pubmed/21746916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103842108
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