c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice

CD44 isoforms act as coreceptors for the receptor tyrosine kinases c-Met and VEGFR-2. However, Cd44 knockout mice do not show overt phenotypes, in contrast to Met and Vegfr-2 knockout mice. We hypothesized that CD44 is being compensated for by another factor in Cd44 null mice. Using RNAi technology...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Olaku, Vivienne, Matzke, Alexandra, Mitchell, Claudia, Hasenauer, Susanne, Sakkaravarthi, Arul, Pace, Giuseppina, Ponta, Helmut, Orian-Rousseau, Véronique
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2011
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145552/
https://ncbi.nlm.nih.gov/pubmed/21680714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-02-0134
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