Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K

Activating PTPN11 mutants promote hematopoietic progenitor hyperactivation of Erk and hypersensitivity to GM-CSF. We hypothesized that Kinase Suppressor of Ras 1 (KSR1) contributes to activating PTPN11-induced GM-CSF hypersensitivity. Bone marrow progenitors from WT and KSR1−/− mice expressing WT Sh...

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Hlavní autoři: Yang, Zhenyun, Chen, Mia, Sitarski, Sarah A, Saadatzadeh, Tirajeh, Yin, Fuqin, Yu, Menggang, Yang, Feng-Chun, Chan, Rebecca J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145485/
https://ncbi.nlm.nih.gov/pubmed/21555152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2011.04.003
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