ALDOSE REDUCTASE PATHWAY CONTRIBUTES TO VULNERABILITY OF AGING MYOCARDIUM TO ISCHEMIC INJURY

Aging men and women display both increased incidence of cardiovascular disease and complications of myocardial infarction and heart failure. We hypothesized that altered glucose metabolism, in particular, flux of glucose via the polyol pathway (PP) may be responsible, in part, for the enhanced vulne...

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Main Authors: Ananthakrishnan, Radha, Li, Qing, Gomes, Teodoro, Schmidt, Ann Marie, Ramasamy, Ravichandran
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144997/
https://ncbi.nlm.nih.gov/pubmed/21600277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2011.05.001
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