ALDOSE REDUCTASE PATHWAY CONTRIBUTES TO VULNERABILITY OF AGING MYOCARDIUM TO ISCHEMIC INJURY

Aging men and women display both increased incidence of cardiovascular disease and complications of myocardial infarction and heart failure. We hypothesized that altered glucose metabolism, in particular, flux of glucose via the polyol pathway (PP) may be responsible, in part, for the enhanced vulne...

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Hoofdauteurs: Ananthakrishnan, Radha, Li, Qing, Gomes, Teodoro, Schmidt, Ann Marie, Ramasamy, Ravichandran
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144997/
https://ncbi.nlm.nih.gov/pubmed/21600277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2011.05.001
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