Receptor-independent Protein Kinase Cα (PKCα) Signaling by Calpain-generated Free Catalytic Domains Induces HDAC5 Nuclear Export and Regulates Cardiac Transcription

Receptor-mediated activation of protein kinase (PK) C is a central pathway regulating cell growth, homeostasis, and programmed death. Recently, we showed that calpain-mediated proteolytic processing of PKCα in ischemic myocardium activates PKC signaling in a receptor-independent manner by releasing...

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Detalhes bibliográficos
Main Authors: Zhang, Yan, Matkovich, Scot J., Duan, Xiujun, Diwan, Abhinav, Kang, Min-Young, Dorn, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143653/
https://ncbi.nlm.nih.gov/pubmed/21642422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234757
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